City of Hope Unveils AI-Powered Platform

City of Hope is pushing the boundaries of cancer care with the launch of HopeLLM, a proprietary generative AI platform designed to save lives, improve care access, and support breakthrough research.

Developed using City of Hope’s expansive oncology expertise and data, HopeLLM is already reshaping the way physicians and patients navigate complex cancer care. The platform streamlines patient onboarding, instantly identifies clinical trial eligibility, extracts real-world data for research, and generates personalized insights based on individual patient records.

“At a time when AI is reshaping nearly every industry, we’re using it to reduce administrative burden and return precious time to our doctors and patients,” said Simon Nazarian, Chief Digital and Technology Officer at City of Hope. “HopeLLM allows us to deliver deeply personalized, data-driven care at scale.”

The impact is substantial. In 2024 alone, City of Hope onboarded over 150,000 new patients—many with decades of medical history. Instead of manually combing through hundreds of pages of records, clinicians can now use HopeLLM to summarize critical information in seconds, freeing up time for more meaningful patient interactions.

“Instead of spending hours on chart review, our doctors can focus on helping patients understand their treatment options,” said Dr. Vijay Trisal, Chief Clinical Officer. “That changes the entire patient experience—from confusion and delay to clarity and connection.”

HopeLLM also accelerates research by extracting data points from patient records into formats ready for analysis, eliminating a traditionally time-intensive step. These capabilities are available across City of Hope’s national clinical network, helping standardize access to world-class care no matter the location.

This launch builds on nearly a decade of AI leadership at City of Hope. Since 2017, the organization has developed and implemented predictive models into clinical workflows to flag risks such as sepsis and surgical complications—providing physicians with real-time, actionable insights backed by explainable AI.

Beyond the clinic, City of Hope is using AI in drug discovery, early detection, and cancer diagnostics—applying advanced algorithms to better understand cancer’s evolution and improve long-term outcomes.

“We’re not just building tools,” said Nasim Eftekhari, Chief AI and Analytics Officer. “We’re building the engine for a learning health system—where every patient interaction accelerates the next breakthrough.”

As cancer cases rise and the demand for precision medicine grows, HopeLLM is a powerful example of how thoughtfully deployed AI can enhance care, boost clinical efficiency, and bring humanity back to the center of the healthcare experience.

To learn more, visit www.cityofhope.org.